NeurosciencebioRxivPreprint
The Alzheimer's disease protective P522R variant of PLCG2, consistently enhances stimulus-dependent PLCγ2 activation, depleting substrate and altering cell function.
Emily Maguire, Georgina Elizabeth Menzies, Tom J. Phillips…·Philip R. Taylor
This paper identifies a protective PLCG2 variant in Alzheimer's disease, showing enhanced PLCγ2 activation and functional changes in immune cells.