Quantification of nuclear protein dynamics reveals chromatin remodeling during acute protein degradation
Alexander Joel Federation, Vivek Nandakumar, Hao Wang, Brian C. Searle, Lindsay K. Pino, Gennifer E. Merrihew, Ying Sonia Ting, Nicholas Howard, Tanya V. Kutyavin, Michael J. MacCoss, John A. Stamatoyannopoulos
This study develops a method to quantify nuclear protein dynamics by isolating chromatin compartments and using mass spectrometry, revealing chromatin remodeling during BET protein degradation.
bioRxiv · Jun 30, 2018 · PreprintSystems Biology