Large-scale single-cell phylogenetic mapping of clonal evolution in the human aging esophagus
Tamara Prieto, Dennis J. Yuan, John Zinno, Clayton Hughes, Nicholas Midler, Sheng Kao, Jani Huuhtanen, Ramya Raviram, Foteini Fotopoulou, Neil G. Ruthen, Srinivas Rajagopalan, Joshua S. Schiffman, Andrew R. D’Avino, Sang-Ho Yoon, Jesús Alfonso López Sotélo, , Dan Avi Landau
This paper develops SMART-PTA for single-cell whole-genome and transcriptome sequencing, revealing clonal evolution in aged human esophageal tissue over 70 years.
bioRxiv · Oct 11, 2025 · PreprintGenomics