Nick Patterson

No evidence for unknown archaic ancestry in South Asia

The paper challenges claims of unknown archaic ancestry in South Asians by showing that supporting statistics do not replicate and contradict the conclusion.

Subtle stratification confounds estimates of heritability from rare variants

This study shows that subtle population stratification can confound heritability estimates from rare variants, even after standard corrections, suggesting the need for better stratification control in genetic studies.

The promise of disease gene discovery in South Asia

This study identifies 81 unique South Asian populations with founder events leading to recessive diseases, highlighting opportunities for disease gene discovery and burden reduction.

Mixed Model Association with Family-Biased Case-Control Ascertainment

This paper introduces LT-Fam, a family-based association statistic that is robust to family-biased case-control ascertainment, showing improved calibration and power compared to existing methods.

Calibrating the Human Mutation Rate via Ancestral Recombination Density in Diploid Genomes

This paper estimates the human mutation rate by analyzing recombination density in diploid genomes, finding a rate between pedigree-based and phylogenetic estimates.

Eight thousand years of natural selection in Europe

This study uses ancient DNA to identify genetic selection signatures in European populations over 8,000 years, finding loci related to diet, pigmentation, immunity, and height.

An Atlas of Genetic Correlations across Human Diseases and Traits

The paper estimates genetic correlations between 25 traits using GWAS summary statistics, identifying correlations like anorexia nervosa with schizophrenia and educational attainment with diseases.

Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis

The paper analyzes the genetic architecture of schizophrenia and nine complex diseases using a fast variance components analysis, finding polygenic patterns and significant genetic correlations.

Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

The paper introduces a new mixed model method for case-control studies that improves association power while controlling false positives, showing gains in power on real and simulated data.

Massive migration from the steppe is a source for Indo-European languages in Europe

The paper analyzes ancient DNA data from 69 Europeans to show that a massive migration from the steppe contributed to the genetic makeup of present-day Europeans and supports a steppe origin for some Indo-European languages.

Efficient Bayesian mixed model analysis increases association power in large cohorts

BOLT-LMM improves genetic association power in large cohorts by using a Bayesian mixture prior to model non-infinitesimal genetic architectures more realistically.

Partitioning heritability by functional category using GWAS summary statistics

This paper partitions heritability across functional genomic elements using GWAS summary statistics to identify trait-specific enrichments.

Non-crossover gene conversions show strong GC bias and unexpected clustering in humans

The paper identifies and analyzes non-crossover gene conversion events in humans, finding strong GC bias and unexpected clustering of conversion tracts.

Ancient human genomes suggest three ancestral populations for present-day Europeans

The paper analyzes ancient genomes to show present-day Europeans derive from three populations: WHG, ANE, and EEF, with EEF having Basal Eurasian ancestry.

Reconstructing Austronesian population history in Island Southeast Asia

This study reconstructs Austronesian population history in Island Southeast Asia using genome-wide data, revealing unexpected ancestry links to Austro-Asiatic populations.