Tumor stiffness creates a ferroptotic Achilles heel through YAP SKP2 signaling
Emma Villares, Nico Taber, Shao-Chin Wu, Connor D. Amelung, Jianli Wu, Chao-Chieh Lin, Jen‐Tsan Chi, Sharon Gerecht
This study identifies ferroptosis as a vulnerability in stiff tumors mediated by YAP-SKP2 signaling, showing that stiff tumors are susceptible to ferroptosis induction despite chemotherapy resistance.
bioRxiv · Oct 2, 2026 · PreprintCancer Biology