Author

Nicolas J. Delalez

University of Oxford

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Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Approach:statistical model· 1

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Aivar SootlaiD· 2 shared Antonis PapachristodoulouiD· 2 shared George H. Wadhams· 2 shared Arthur Norman· 1 shared Emmanouil AlexisiD· 1 shared Harrison SteeliD· 1 shared

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2018-2022 · peak 1/yr

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2 shared papersSynthetic Biology

Aivar SootlaORCID

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Recent·Most cited

Synthetic BiologyJournal of The Royal Society InterfacePeer-reviewedApr 1, 2022

Dichotomous Feedback: A Signal Sequestration-based Feedback Mechanism for Biocontroller Design

Aivar Sootla, Nicolas J. Delalez, Emmanouil Alexis…·Antonis Papachristodoulou

This paper introduces a new feedback mechanism for synthetic biology, dichotomous feedback, which uses signal sequestration to improve robustness and reduce noise in biological systems.

14 citations

experimental assay

Synthetic BiologybioRxivPreprintDec 21, 2018

Design of a Synthetic sRNA-based Feedback Filter Module

Nicolas J. Delalez, Aivar Sootla, George H. Wadhams, Antonis Papachristodoulou

The paper designs and tests a synthetic sRNA-based feedback filter module that reduces noise and tunes feedback strength through mathematical modeling and experimental validation.

4 citations

statistical model