"Double-dipping" in testing for phenotypic differences with scRNA-Seq
Nicolas Sanchez, Lucas Etourneau, Elizabeth A. Purdom
The paper identifies a 'double-dipping' issue in scRNA-Seq where cell-type clustering and phenotype testing are performed on the same data, leading to inflated false discovery rates, and proposes solutions to mitigate this problem.
bioRxiv · Oct 6, 2026 · PreprintBioinformatics