High-avidity TCR signaling drives an NKG2A-positive CD8 T cell exhaustion state in human tumors
Riley D. Z. Mullins, Jesse Meir Zaretsky, Thomas F. Barrett, Emily Stoller, Porter Bischoff, Ann Marie Egloff, Cody Huffman, Salma Ramadan, Amna Ramadan, Jessica C. Ley, Katherine E. Schwetye, D K Miller, Jennifer De Los Santos, Anthony J. Apicelli, Nikhil Rammohan, , Ravindra Uppaluri
This study identifies high-avidity TCR signaling via NFAT as a key driver of NKG2A-positive CD8 T cell exhaustion in human tumors, with implications for immunotherapy.
bioRxiv · Aug 27, 2026 · PreprintImmunology