Divergent malignant evolution converges on shared immunosuppressive ecosystems through tumor-intrinsic TMED2-ADAR1-dependent complement signalling in multifocal hepatocellular carcinoma
Cheng Wu, Ke Si, Shuai Mao, Zehang Jiang, D. Z. Li, Haipeng Zhu, Ningning Sun, Weiling Liang, Wenliang Zhang
This study identifies shared immunosuppressive mechanisms in multifocal hepatocellular carcinoma despite divergent tumor evolution, highlighting a TMED2-ADAR1-C3/C5 complement axis as a potential therapeutic target.
bioRxiv · Aug 19, 2026 · PreprintCancer Biology