GATA3-extension mutants rewire lineage identity in luminal breast cancer
Nivedhya Venas, Mrunal Ratnaparkhi, Kartik Majila, Stacey Jamieson, Igor V. Chernukhin, Shruthi Viswanath, Jason S. Carroll, Dimple Notani, Radhakrishnan Sabarinathan
The paper shows that eGATA3 mutations alter transcriptional regulation and lineage identity in luminal breast cancer without losing DNA-binding function.
bioRxiv · Aug 24, 2026 · PreprintCancer Biology