Quantification method affects replicability of eQTL analysis, colocalization, and TWAS
S. Taylor Head, Sean T. Bresnahan, Yung-Han Chang, Vihan Shah, Nolan Cole, William Wu, Arjun Bhattacharya
The paper shows that RNA-seq quantification methods and reference annotations significantly impact eQTL analysis, colocalization, and TWAS results across multiple tissues and phenotypes.
Nature Genetics · Oct 26, 2026Peer-reviewedGenomics