Nucleotide excision repair is impaired by binding of transcription factors to DNA
Radhakrishnan Sabarinathan, Loris Mularoni, Jordi Deu-Pons, Abel Gonzalez-Perez, Nuria Lopez-Bigas
The paper shows that DNA-binding proteins reduce nucleotide excision repair activity, leading to higher mutation rates at their binding sites in melanoma.
bioRxiv · Oct 13, 2015Genomics