Functional binding of PD1 ligands predicts response to anti-PD1 treatment in cancer patients
B. Kaufman, O. Abramov, A. Yevko, D. Apple, M. Shlapobersky, Y. Greenshpan, R. Shaco-Levy, K. Rouvinov, A. Livoff, M. Elkabets, A. Porgador
The paper develops a method to predict response to anti-PD1 therapy by measuring PDL1 and PDL2 binding functionality, finding it more effective than protein expression alone.
bioRxiv · Feb 9, 2023Immunology