Unexpected implications of STAT3 acetylation revealed by genetic encoding of acetyl-lysine
Y. Belo, Z. Mielko, H. Nudelman, A. Afek, O. Ben-David, A. Shahar, R. Zarivach, R. Gordan, E. Arbely
This study genetically encodes acetyl-lysine into STAT3 to investigate its effects on structure and DNA binding, revealing that acetylation does not directly alter these properties but may require additional factors for transcriptional regulation.
bioRxiv · May 30, 2019Biochemistry