Unscheduled origin building in S-phase upon tight CDK1 inhibition suppresses CFS instability
O. BRISON, S. Gnan, D. Azar, M. Schmidt, S. KOUNDRIOUKOFF, S. El-Hilali, Y. Jaszczyszyn, A.-M. Lachages, C. Thermes, C.-L. Chen, M. Debatisse
The paper shows that tight CDK1 inhibition during S-phase reduces CFS instability by promoting extra replication origins in under-replicated regions.
bioRxiv · Nov 19, 2020 · PreprintCell Biology