A novel dimeric active site and regulation mechanism revealed by the crystal structure of iPLA2β
K. R. Malley, O. Koroleva, I. Miller, R. Sanishvili, C. M. Jenkins, R. W. Gross, S. Korolev
The paper presents the first crystal structure of iPLA2β, revealing a dimeric active site and regulation mechanism that could inform therapeutic inhibitor development.
bioRxiv · Sep 29, 2017Biochemistry