S-acylation controls SARS-Cov-2 membrane lipid organization and enhances infectivity
F. S. Mesquita, L. Abrami, O. Sergeeva, P. Turelli, B. Kunz, C. Raclot, J. Paz Montoya, L. Abriata, M. Dal Peraro, D. Trono, G. D'Angelo, F. G. van der Goot
The paper shows that S-acylation by ZDHHC20 modifies SARS-CoV-2 membrane proteins, promoting lipid domain formation and enhancing viral infectivity.
bioRxiv · Mar 14, 2021Cell Biology