L1CAMxCD3 bispecific antibodies exert potent anti-tumor effects in preclinical pancreatic cancer models considering the complex tumor stroma
Anna Maxi Wandmacher, Annika Bräuer, Charlotte Kayser, Caj Stach, Jakob Werner, Silje Beckinger, Tina Daunke, Leon Baumann, Benjamin Heckelmann, Ashini Kumar Hidam, Olha Lapshyna, Daniela Wesch, Anne‐Sophie Mehdorn, Christoph Röcken, Ruediger Braun, , Susanne Sebens
This study shows L1CAMxCD3 bispecific antibodies effectively target PDAC cells in immunosuppressive models, inducing apoptosis and T cell effector molecule release.
bioRxiv · Aug 19, 2026 · PreprintCancer Biology