Author

Orla Hardiman

Trinity College Dublin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 1 Research Focus:GWAS / association mapping· 1 Assay:protein structure· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Ahmad Al KhleifatiD· 3 shared Alfredo IacoangeliiD· 3 shared Ammar Al‐ChalabiiD· 3 shared Christopher E. ShawiD· 3 shared Jan Herman VeldinkiD· 3 shared John E. LandersiD· 3 shared Leonard H. van den BergiD· 3 shared Philip Van DammeiD· 3 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Ahmad Al KhleifatORCID

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Author profile →

3 papers

Recent·Most cited

Sex-specific DNA methylation differences in Amyotrophic lateral sclerosis

Olivia A. Grant, Alfredo Iacoangeli, Ramona A.J. Zwamborn, Wouter van Rheenen, Ross Patrick Byrne, Kristel R. van Eijk, Kevin Patrick Kenna, Joke J.F.A. van Vugt, Johnathan Cooper‐Knock, Brendan Kenna, Atay Vural, Simon D. Topp, Yolanda Campos, Markus Weber, Bradley N. Smith, , Ahmad Al Khleifat

The paper identifies sex-associated DNA methylation differences in ALS using a large-scale epigenome-wide association study and links them to survival outcomes.

bioRxiv · Nov 22, 2024 · PreprintGenomics

Molecular dynamics analysis of Superoxide Dismutase 1 mutations suggests decoupling between mechanisms underlying ALS onset and progression

Munishikha Kalia, Mattia Miotto, Deborah Ness, Sarah Opie-Martin, Thomas P Spargo, Lorenzo Di Rienzo, Tommaso Biagini, Francesco Petrizzelli, Ahmad Al Khleifat, Renata Kabiljo, Simon Topp, Keith Mayl, Isabella Fogh, Puja R. Mehta, Kelly L. Williams, , Alfredo Iacoangeli

This study uses molecular dynamics and clinical data to show structural and dynamic differences between WTL and MBR SOD1 variants, linking these to distinct ALS clinical outcomes.

Computational and Structural Biotechnology Journal · Jan 1, 2023Peer-reviewedNeuroscience

Project MinE: study design and pilot analyses of a large-scale whole-genome sequencing study in amyotrophic lateral sclerosis

Wouter van Rheenen, Sara L. Pulit, Annelot M. Dekker, Ahmad Al Khleifat, William J. Brands, Alfredo Iacoangeli, Kevin Patrick Kenna, Maarten Kooyman, Russell Lewis McLaughlin, Bas M Middelkoop, Matthieu Moisse, Raymond D. Schellevis, Aleksey Shatunov, William Sproviero, Gijs H.P. Tazelaar, , Jan Herman Veldink

Project MinE analyzes whole-genome sequencing data from ALS patients and controls to study genetic variation and its implications for disease susceptibility.

European Journal of Human Genetics · Jun 28, 2018Peer-reviewedGenetics