Lipogenesis and innate immunity in hepatocellular carcinoma cells reprogrammed by an isoenzyme switch of hexokinases
L. Perrin-Cocon, P.-O. Vidalain, C. Jacquemin, A. Aublin-Gex, K. Olmstead, B. Panthu, G. J. P. Rautureau, P. Andre, P. Nyczka, M.-T. Hutt, N. Amoedo, R. Rossignol, F. V. Filipp, V. Lotteau, O. Diaz
This study shows that switching hexokinase isoenzymes in HCC cells alters metabolism and reactivates innate immunity, improving survival outcomes.
bioRxiv · Mar 13, 2020 · PreprintCancer Biology