Auranofin induces disulfide bond-mimicking S-Au-S bonds in protein thiol pairs
L. Quadros Barse, P. Duchting, N. Lupilov, J. E. Bandow, U. Kramer, L. I. Leichert
This study shows auranofin forms S-Au-S bonds between cysteine thiols in proteins, independent of thioredoxin reductase, suggesting a new mechanism for its antibacterial activity.
bioRxiv · Jan 15, 2024 · PreprintBiochemistry