Supramolecular cylinders target bulge structures in the 5-prime UTR of the RNA genome of SARS-CoV-2 and inhibit viral replication
L. Melidis, H. J. Hill, N. J. Coltman, S. P. Davies, K. Winczura, T. Chauhan, J. S. Craig, A. Garai, C. A. J. Hooper, R. T. Egan, J. A. McKeating, N. J. Hodges, Z. Stamataki, P. Grzechnik, M. J. Hannon
The paper models the 5' UTR structure of SARS-CoV-2 and shows supramolecular cylinders bind to a bulge and junction, inhibiting viral replication.
bioRxiv · Mar 30, 2021Biochemistry