EWS-FLI-1 creates a cell surface microenvironment conducive to IGF signaling by inducing pappalysin-1.
P. Jayabal, P. J. Houghton, Y. Shiio
This study shows EWS-FLI-1 promotes IGF signaling by inducing pappalysin-1, which degrades IGFBPs and enhances IGF bioavailability, making pappalysin-1 a potential therapeutic target in Ewing sarcoma.
bioRxiv · Sep 28, 2017Cancer Biology