Author

P. Kotanko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Cherif· 1 shared A. Mermelstein· 1 shared A. N. Moreno-Amaral· 1 shared B. A. Kondo Van Spitzenbergen· 1 shared D. A. Bushinsky· 1 shared D. H. Fuertinger· 1 shared D. J. Jörg· 1 shared E. S. Dias· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Cherif

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

The protein-bound uremic solute 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) increases erythrocyte osmotic fragility through interaction with the mechanosensitive channel Piezo1.

B. A. Kondo Van Spitzenbergen, G. Bohnen, E. S. Dias, J. B. Monte Alegre, G. F. Dias, N. Grobe, A. N. Moreno-Amaral, P. Kotanko

The paper shows CMPF increases erythrocyte osmotic fragility by activating Piezo1, similar to Jedi1, and this effect is blocked by the Piezo1 inhibitor GsMTx-4.

bioRxiv · May 26, 2023 · PreprintCell Biology

Modeling osteoporosis to design and optimize pharmacologic therapies comprising multiple drug types

D. J. Jörg, D. H. Fuertinger, A. Cherif, D. A. Bushinsky, A. Mermelstein, J. G. Raimann, P. Kotanko

The paper develops a mathematical model to optimize drug combinations for postmenopausal osteoporosis by simulating synergistic effects of different drug classes.

bioRxiv · Dec 17, 2021 · PreprintPharmacology & Toxicology