On the feasibility of mining CD8+ T-cell receptor patterns underlying immunogenic peptide recognition.
N. De Neuter, W. Bittremieux, C. Beirnaert, B. Cuypers, A. Mrzic, P. Moris, A. Suls, V. Van Tendeloo, B. Ogunjimi, K. Laukens, P. Meysman
The paper develops a random forest classifier to predict T-cell receptor recognition of peptides and identifies structural CDR3 features associated with immunogenicity.
bioRxiv · Mar 20, 2017Immunology