Origin of Fe ions in ROS production induced in magnetic hyperthermia anti-cancer nanotherapy: release from iron oxide nanoparticles or not?
Justine Journaux, Megi Bejko, Pascal Clerc, Yasmina Al Yaman, Ahmed Gamal Ali Abdelhamid, G. Ballon, Corinne Bousquet, Julian Carrey, Stéphane Mornet, Olivier Sandre, Véronique Gigoux
The paper investigates whether Fe ions released from iron oxide nanoparticles are necessary for ROS production in magnetic hyperthermia anti-cancer therapy, finding that ROS production and cell death can occur without Fe3+ release.
bioRxiv · Jul 8, 2026 · PreprintCancer Biology