Isostere 18F-protein post-translational editing enables dynamic tracking of neurodegeneration biomarkers
Nan Yang, Adeline W. J. Poh, Andrew M. Giltrap, Patrick G. Isenegger, Jeroen B. I. Sap, Joseph Ford, Tatsiana Auchynnikava, Kel Vin Tan, Sarah Able, Nikita Levin, Matthew Davy, Brian Josephson, Yue Yu, Maxwell W. G. Miner, Jatta S. Helin, , Benjamin G. Davis
This paper introduces a method to track neurodegeneration biomarkers using PET imaging with isosteric protein mimics, revealing spinal fluid dynamics and neuronal loss mechanisms.
bioRxiv · Jan 26, 2025 · PreprintSynthetic Biology