A single cell multi-omic analysis identifies molecular and gene-regulatory mechanisms dysregulated in the developing Down syndrome neocortex
Celine K. Vuong, Alexis Weber, Patrick Seong, Nana Matoba, Yu-Jen Chen, Jordan Peyer, Shahab Younesi, Angelo Salinda, Daniel Gomez, Gabriella Rivas, Abril Morales, Beck Shafie, Pan Zhang, Susanne Nichterwitz, Le Qi, , Luis de la Torre-Ubieta
This study uses single-nucleus multi-omics to analyze the developing Down syndrome neocortex, identifying dysregulated molecular and gene-regulatory mechanisms affecting neurogenesis and cell specification.
Science · Apr 23, 2026Peer-reviewedGenomics