Breast Cancer-derived PDGFB Remodels the CNS Vascular Niche to Promote Brain, Spinal and Leptomeningeal Metastasis
Nathaniel S Grabinski, Jesse J. Reardon, Sajita Shah, Jonathan J. Adorno, Paul Lee, Rebecca Packard, Yalini Ramamoorthy, Katie Thies, Prathik A. Chakravarthy, Shashwat Agarwal, Jonathan M. Spehar, Tasneem A. Arsiwala, James W Carpenter, Alexis Mossing, Johnathon G. Schiebel, , Gina M. Sizemore
This study shows that breast cancer-derived PDGFB remodels the CNS vascular niche, promoting brain, spinal, and leptomeningeal metastasis through multiple mechanisms.
bioRxiv · Oct 16, 2026 · PreprintCancer Biology