Validation of TRIzol-Based Inactivation Protocol with Failure Scenario Testing for Bacterial Select Agent Surrogates
Umar Raza Shahid, Paul Lueth, Bellaire Bryan
The paper validates TRIzol-based inactivation protocols for bacterial surrogates by testing failure scenarios and shows that complete protocol adherence is necessary for reliable inactivation, especially for spore-forming bacteria.
bioRxiv · Feb 22, 2026 · PreprintMicrobiology