Convergent and clonotype-enriched mutations in the light chain drive affinity maturation of a public antibody
Vishal Rao, Iden A. Sapse, Hallie Cohn, Duck-Kyun Yoo, Pei Tong, Jordan Clark, Bailey Bozarth, Yuexing Chen, Komal Srivastava, Gagandeep Singh, Florian Krammer, Viviana R. Simon, Duane R. Wesemann, Goran Bajic, Camila H. Coelho
The paper identifies clonotype-enriched mutations in the light chain of a public antibody that enhance affinity for a conserved viral epitope and increase after repeated vaccinations.
bioRxiv · Mar 7, 2025 · PreprintImmunology