Harnessing A Unified Multi-modal SequenceModeling to unveil Protein-DNA Interdependency
Mingchen Li, Yuchen Ren, Peng Ye, Jiabei Cheng, Xinzhu Ma, Yuchen Cai, Wanli Ouyang, Bozitao Zhong, Banghao Wu, Nanqing Dong, Liang Hong, Pan Tan
ProDMM is a multimodal sequence modeling framework that captures interdependencies between protein motifs, coding DNA, and regulatory elements to predict phenotypes and generate optimized regulatory sequences.
bioRxiv · Feb 26, 2025 · PreprintBioinformatics