Generalizable virtual staining from histopathology to spatial proteomics across biological scales
Yufan Liu, Oded Falik, Zihan Zhong, Lequan Yu, Ruibang Luo, Cheng Jin, Hao Chen, Aaron T. Mayer, Alexandro E. Trevino, Peter Chou, Yue Dai, Zhenqin Wu
This study introduces QUEST, a model that uses H&E histology to predict spatial protein expression, enabling virtual staining and analysis across biological scales.
bioRxiv · Nov 4, 2026 · PreprintBioinformatics