Allosteric disulfide control of ligand binding and endocytosis of KIR2DL4, the natural killer cell receptor for HLA-G
Sumati Rajagopalan, Joyce Chiu, Priyanka Chaurasia, Jinghua Lu, George M Mastorakos, Saurav Majumder, Kristof Nolan, Jan Petersen, Erin J. Adams, Peter D Sun, Jamie Rossjohn, Philip J. Hogg, Eric O. Long
This study identifies an allosteric disulfide bond in KIR2DL4 that regulates HLA-G binding and endocytosis, influencing NK cell function during pregnancy.
eLife · Oct 13, 2026Peer-reviewedImmunology