The Alzheimer's disease risk factor APOE4 drives pro-inflammation in human astrocytes via HDAC-dependent repression of TAGLN3
Laurie Arnaud, Philippe D. Benech, Louise Greetham, Delphine Stephan, Angélique Jimenez, Nicolas D. Jullien, Laura García‐González, Philipp O. Tsvetkov, François Devred, Ignacio Sancho-Martinez, Juan-Carlos Izpisua Belmonte, Kévin Baranger, Santiago Rivera, Emmanuel Nivet
This study shows APOE4 promotes inflammation in human astrocytes by repressing TAGLN3 through HDAC activity, linking it to Alzheimer's disease pathology.
bioRxiv · Apr 16, 2021 · PreprintNeuroscience