Author

Philippe Frossard

Center for Non-Communicable Diseases

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 2 Genomics· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Assay:whole-exome sequencing· 2 Research Focus:database / resource· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Assay:metabolomics· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Asif Rasheed· 4 shared John DaneshiD· 4 shared Danish SaleheeniD· 3 shared Mohammad IshaqiD· 3 shared Shahid Abbas· 3 shared Adam S. ButterworthiD· 2 shared Anis Memon· 2 shared Anjum JalaliD· 2 shared

Activity by Year

2015-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenetic & Genomic Medicine

Asif Rasheed

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4 papers

Recent·Most cited

NOTCH3 p.Arg1231Cys is Markedly Enriched in South Asians and Associated with Stroke

Juan L. Rodríguez-Flores, Shareef Khalid, Neelroop Parikshak, Asif Rasheed, Bin Ye, Manav Kapoor, Joshua Backman, Farshid Sepehrband, Silvio Alessandro Di Gioia, Sahar Gelfman, Tanima De, Nilanjana Banerjee, Deepika Sharma, Hector Martinez, Sofia Castaneda, , Danish Saleheen

The paper identifies a NOTCH3 variant, p.Arg1231Cys, enriched in South Asians and strongly associated with stroke risk, highlighting the importance of genetic diversity in stroke research.

medRxiv · Oct 5, 2023 · PreprintGenetic & Genomic Medicine

Genome-wide analysis of blood lipid metabolites in over 5,000 South Asians reveals biological insights at cardiometabolic disease loci

Eric L. Harshfield, Eric B. Fauman, David Stacey, Dirk S. Paul, Daniel Ziemek, Rachel M. Y. Ong, John Danesh, Adam S. Butterworth, Asif Rasheed, Taniya Sattar, Zameer-ul-Asar, Imran Saleem, Zoubia Hina, Unzila Ishtiaq, Nadeem Qamar, , Albert Koulman

The paper identifies genetic associations between blood lipid metabolites and cardiometabolic disease loci in South Asian populations using lipidomics data from two studies.

BMC Medicine · Sep 9, 2021Peer-reviewedGenetic & Genomic Medicine

South Asian patient population genetics reveal strong founder effects and high rates of homozygosity - new resources for precision medicine

Jeffrey D. Wall, J. Fah Sathirapongsasuti, Ravi Kr Gupta, Anamitra Barik, Rajesh Kumar, Asif Rasheed, Venkatesan Radha, Saurabh Belsare, Ramesh Menon, Sameer Phalke, Anuradha Mittal, John Z. Fang, Deepak Tanneeru, Manjari Deshmukh, Akshi Bassi, , Andrew S. Peterson

The paper characterizes the genetic structure of South Asian populations, identifies founder effects and high homozygosity, and develops a custom SNP array for genetic studies in the region.

bioRxiv · Oct 2, 2020 · PreprintGenomics

Human knockouts in a cohort with a high rate of consanguinity

Danesh Saleheen, Pradeep Natarajan, Wei Zhao, Asif Rasheed, Sumeet Khetarpal, Hong-Hee Won, Konrad J Karczewski, Anne H ODonnell-Luria, Kaitlin E Samocha, Namrata Gupta, Mozzam Zaidi, Maria Samuel, Atif Imran, Shahid Abbas, Faisal Majeed, , Sekar Kathiresan

The paper identifies homozygous null mutations in 961 genes in a consanguineous Pakistani cohort and reports their phenotypic consequences.

bioRxiv · Nov 12, 2015Genomics