Author

Asif Rasheed

Center for Non-Communicable Diseases

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 4 Genomics· 3 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 8 Approach:statistical model· 8 Research Focus:GWAS / association mapping· 4 Assay:whole-exome sequencing· 3 Research Focus:gene regulatory network inference· 2 Assay:GWAS summary statistics· 2 Assay:bulk RNA-seq· 1 Assay:clinical cohort / trial· 1

Frequent Co-Authors

John DaneshiD· 5 shared Philippe Frossard· 4 shared Shahid Abbas· 4 shared Anjum JalaliD· 3 shared Austin T. HilliardiD· 3 shared Danish SaleheeniD· 3 shared David R. WeiriD· 3 shared Derek M. KlariniD· 3 shared

Activity by Year

2015-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersGenetic & Genomic Medicine

John DaneshORCID

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8 papers

Recent·Most cited

NOTCH3 p.Arg1231Cys is Markedly Enriched in South Asians and Associated with Stroke

Juan L. Rodríguez-Flores, Shareef Khalid, Neelroop Parikshak, Asif Rasheed, Bin Ye, Manav Kapoor, Joshua Backman, Farshid Sepehrband, Silvio Alessandro Di Gioia, Sahar Gelfman, Tanima De, Nilanjana Banerjee, Deepika Sharma, Hector Martinez, Sofia Castaneda, , Danish Saleheen

The paper identifies a NOTCH3 variant, p.Arg1231Cys, enriched in South Asians and strongly associated with stroke risk, highlighting the importance of genetic diversity in stroke research.

medRxiv · Oct 5, 2023 · PreprintGenetic & Genomic Medicine

Implicating genes, pleiotropy and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Stavroula Kanoni, Sarah E. Graham, Yuxuan Wang, Ida L. Surakka, Shweta Ramdas, Xiang Zhu, Shoa L. Clarke, Konain Fatima Bhatti, Sailaja Vedantam, Thomas W. Winkler, Adam E. Locke, Eirini Marouli, Greg J. M. Zajac, Kuan-Han Wu, Ιωάννα Ντάλλα, , Pala Mauro

This study identifies 118 candidate causal genes and 21 novel lipid loci on the X chromosome through a multi-ancestry meta-analysis of blood lipid levels, revealing sex-biased effects and pleiotropy with cardiovascular and hormonal traits.

Genome biology · Dec 27, 2022Peer-reviewedGenetic & Genomic Medicine

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

Shweta Ramdas, Jonathan Judd, Sarah E. Graham, Stavroula Kanoni, Yuxuan Wang, Ida L. Surakka, Brandon M. Wenz, Shoa L. Clarke, Alessandra Chesi, Andrew D. Wells, Konain Fatima Bhatti, Sailaja Vedantam, Thomas W. Winkler, Adam E. Locke, Eirini Marouli, , Maria Sabater‐Lleal

This paper integrates GWAS data with functional genomic datasets to identify regulatory mechanisms and causal genes underlying lipid-related traits.

The American Journal of Human Genetics · Aug 1, 2022Peer-reviewedGenomics

Genome-wide analysis of blood lipid metabolites in over 5,000 South Asians reveals biological insights at cardiometabolic disease loci

Eric L. Harshfield, Eric B. Fauman, David Stacey, Dirk S. Paul, Daniel Ziemek, Rachel M. Y. Ong, John Danesh, Adam S. Butterworth, Asif Rasheed, Taniya Sattar, Zameer-ul-Asar, Imran Saleem, Zoubia Hina, Unzila Ishtiaq, Nadeem Qamar, , Albert Koulman

The paper identifies genetic associations between blood lipid metabolites and cardiometabolic disease loci in South Asian populations using lipidomics data from two studies.

BMC Medicine · Sep 9, 2021Peer-reviewedGenetic & Genomic Medicine

South Asian patient population genetics reveal strong founder effects and high rates of homozygosity - new resources for precision medicine

Jeffrey D. Wall, J. Fah Sathirapongsasuti, Ravi Kr Gupta, Anamitra Barik, Rajesh Kumar, Asif Rasheed, Venkatesan Radha, Saurabh Belsare, Ramesh Menon, Sameer Phalke, Anuradha Mittal, John Z. Fang, Deepak Tanneeru, Manjari Deshmukh, Akshi Bassi, , Andrew S. Peterson

The paper characterizes the genetic structure of South Asian populations, identifies founder effects and high homozygosity, and develops a custom SNP array for genetic studies in the region.

bioRxiv · Oct 2, 2020 · PreprintGenomics

Discovery of 318 novel loci for type-2 diabetes and related micro- and macrovascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis.

Marijana Vujković, Jacob M. Keaton, Julie Ann Lynch, Donald R. Miller, Jin J. Zhou, Catherine Tcheandjieu, Jennifer E. Huffman, Themistocles L. Assimes, Kimberly Lorenz, Xiang Zhu, Austin T. Hilliard, Renae Judy, Jie Huang, Kyung Min Lee, Derek M. Klarin, , Saib S. Gappy

Multi-ethnic type 2 diabetes (T2D) meta-analysis of 228,499 cases and 1,178,783 controls finds 318 previously unreported loci, 804 expression-colocalized genes, and 13 SNP-by-T2D vascular-outcome interactions.

Nature Genetics · Jun 15, 2020Peer-reviewedGenetic & Genomic Medicine✦ In-depth digest

Exome chip meta-analysis elucidates the genetic architecture of rare coding variants in smoking and drinking behavior

David M. Brazel, Yu Jiang, Jordan M. Hughey, Valérie Turcot, Xiaowei Zhan, Jian Gong, Chiara Batini, J. Dylan Weissenkampen, Mengzhen Liu, Daniel R. Barnes, Sarah E. Bertelsen, Yi‐Ling Chou, Abdullah Mesut Erzurumluoglu, Jessica D. Faul, Jeff Haessler, , Jean Ferrières

The paper analyzes rare coding variants in smoking and drinking behavior using exome chip data, finding that they contribute to phenotypic variation but require larger samples for individual variant associations.

Biological Psychiatry · Dec 6, 2018Peer-reviewedGenetics

Human knockouts in a cohort with a high rate of consanguinity

Danesh Saleheen, Pradeep Natarajan, Wei Zhao, Asif Rasheed, Sumeet Khetarpal, Hong-Hee Won, Konrad J Karczewski, Anne H ODonnell-Luria, Kaitlin E Samocha, Namrata Gupta, Mozzam Zaidi, Maria Samuel, Atif Imran, Shahid Abbas, Faisal Majeed, , Sekar Kathiresan

The paper identifies homozygous null mutations in 961 genes in a consanguineous Pakistani cohort and reports their phenotypic consequences.

bioRxiv · Nov 12, 2015Genomics