An alignment-last approach enables rapid transcriptomic biomarker discovery in large cohorts
Erkan Narmanli, Alexandre Lanau, Mara Neacsu, Maria K. Koshkina, Pierre Fumeron, Philippe Martin, Nicolas Servant, Nicolas Perrin, Joshua J. Waterfall
This paper introduces an alignment-last approach to transcriptomic analysis, enabling rapid biomarker discovery by using reads directly and revealing new transposable-element signatures and prognostic reads in cancer.
bioRxiv · Sep 3, 2026 · PreprintBioinformatics