CRlSPR/Cas9 screening revealed BlRC6-AS1/BlRC6 mediates abiraterone resistance via NHEJ pathway-dependent A20 degradation in prostate cancer
Lan Li, Xue-Ni An, Yongtong Ruan, Rong Yang, Li Peng, Xiaoyu Wu, Xian-Chao Huang, Ping Gao, Xiaoming Dong
The paper identifies BIRC6-AS1/BIRC6 as a driver of abiraterone resistance in prostate cancer by stabilizing BIRC6 and promoting A20 degradation via NHEJ pathway disruption.
bioRxiv · Oct 1, 2025 · PreprintMolecular Biology