Multi-Omics Reveals Activated Fibroblasts with Dual Functional Roles in Repair and Negative Barrier in the CD8+ T Cell Cytotoxic Niche for Lung Cancer Neoadjuvant Therapy
Ruihan Zhou, Chaoxin Xiao, Ping Zhou, Ouying Yan, Banglei Yin, Xiaohong Yao, Jiaxin Liu, Xuexue Wu, WW Hou, Yulin Wang, Huanhuan Wang, Rui Zhu, Zirui Wang, Leyi Yao, Xiaoying Li, , Chengjian Zhao
The paper introduces NICHE, a multi-omics framework to analyze immune niches in lung cancer, revealing fibroblasts with dual roles in tissue repair and immunosuppression.
bioRxiv · Jan 15, 2026 · PreprintImmunology