Loss of Propionyl-CoA Carboxylase Reprograms Hepatic Metabolism by Suppressing Mitochondrial Pyruvate Carboxylation and Fatty Acid Oxidation
Fang Lu, Chorlada Paiboonrungruang, Wentao He, Zhaohui Xiong, Pingchuan Tang, Takhar Kasumov, Xiaoxin Luke Chen, Guofang Zhang
This study investigates metabolic changes in PCCA-deficient hepatocytes, showing reduced fatty acid oxidation and pyruvate carboxylation, leading to impaired gluconeogenesis and lipid synthesis.
bioRxiv · Apr 15, 2026 · PreprintGenetics