THAP9 transposase cleaves DNA via conserved acidic residues in an RNaseH-like domain
Vasudha Sharma, Prachi Thakore, Sharmistha Majumdar
This study identifies a conserved DDE motif in hTHAP9's catalytic domain, essential for DNA cleavage, and finds a residue mutation that increases transposition activity.
Cells · May 29, 2021Peer-reviewedMolecular Biology