Acute stress reorganizes pregenual cingulate and subthalamic coupling to approach-avoidance decisions in remitted depression
Manuel Kuhn, Nadja Rita Ging-Jehli, Emma Holly Palermo, Pranavan Chanthrakumar, Swarag Thaikkandi, Zeyang Yu, Jacob M. Blank, David C. Steinberger, Yinru Long, Genevieve P. Nowicki, Todd M. Herrington, Daniel G. Dillon, Ann M. Graybiel, Michael R. Bruchas, Michael J. Frank, Diego A. Pizzagalli
This study shows that acute stress reorganizes neural coupling in rMDD patients during decision-making, predicting future depressive symptoms.
bioRxiv · Oct 16, 2026 · PreprintNeuroscience