Author

Pratima Chapagain

Vanderbilt University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Raymond D. BlindiD· 3 shared Lucia E. RamehiD· 2 shared Andrew T. HaleiD· 1 shared Desmarini DesmariniiD· 1 shared Dilipkumar UrediiD· 1 shared Elizabeth StivisoniD· 1 shared Gregory A. SowdiD· 1 shared Hundaol Huluka· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBiochemistry

Raymond D. BlindORCID

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3 papers

Recent·Most cited

Design, synthesis and cellular characterization of a new class of IPMK kinase inhibitors

Yubai Zhou, Pratima Chapagain, Desmarini Desmarini, Dilipkumar Uredi, Michael A. Stashko, Hundaol Huluka, Lucia E. Rameh, Julianne T. Djordjevic, Raymond D. Blind, Xiaodong Wang

This study designs, synthesizes, and characterizes a new class of IPMK kinase inhibitors, showing reduced glioblastoma cell growth and a novel InsP5 metabolic signature.

Journal of Medicinal Chemistry · Jul 25, 2025Peer-reviewedPharmacology & Toxicology

Bilirubin is a new ligand for nuclear receptor Liver Receptor Homolog-1.

Pratima Chapagain, Zeinab Haratipour, M. Merced Malabanan, Woong Jae Choi, Raymond D. Blind

This study identifies bilirubin as a direct ligand for LRH-1, showing it modulates LRH-1 activity and gene regulation in liver cells.

bioRxiv · May 5, 2024 · PreprintBiochemistry

IPMK regulates HDAC3 activity and histone H4 acetylation in human cells.

Gregory A. Sowd, Elizabeth Stivison, Pratima Chapagain, Andrew T. Hale, James C. Poland, Lucia E. Rameh, Raymond D. Blind

This study shows IPMK regulates HDAC3 activity and histone H4 acetylation in human cells through inositol phosphate production.

bioRxiv · Apr 29, 2024 · PreprintBiochemistry