The SP140-RESIST pathway regulates interferon mRNA stability and antiviral immunity
Kristen C. Witt, Adam Dziulko, Joohyun An, Filip Pekovic, Arthur Xiuyuan Cheng, Grace Y. Liu, Ophelia V. Lee, David J. Turner, A. C. Lari, Moritz M. Gaidt, Roberto A. Chavez, Stefan A. Fattinger, Preethy Abraham, Harmandeep S Dhaliwal, Angus Y. Lee, , Russell E. Vance
This study identifies SP140's role in regulating IFN-β mRNA stability through RESIST, revealing a dual antiviral and interferon regulatory function.
Nature · Jun 11, 2025Peer-reviewedImmunology