Identification of the interaction of 2-aminosteroids with G-quadruplex in BCR/ABL gene promoter: An emerging potential target for treatment of human chronic myelogenous leukemia
The paper investigates how aminosteroids interact with G-quadruplex structures in the BCR/ABL gene promoter, showing they inhibit mRNA expression by stabilizing the G-quadruplex, offering a new therapeutic strategy for CML.
bioRxiv · May 2, 2018 · PreprintCancer Biology