Coding variants identified in diabetic patients alter PICK1 BAR domain function in insulin granule biogenesis
R. C. Andersen, M. D. Lycas, J. H. Schmidt, N. R. Christensen, V. K. Lund, J. Rombach, M. Stoklund, D. Stapleton, G. Noes-Holt, M. P. Keller, A. M. Jansen, R. Herlo, O. Kjaerulff, B. Holst, A. D. Attie, , k. L. Madsen
The paper identifies coding variants in PICK1 that impair its BAR domain function, leading to altered insulin granule biogenesis in diabetic patients.
bioRxiv · Oct 5, 2020Cell Biology