Author

R. Lopez-Astacio

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

C. R. Parrish· 2 shared E. C. Holmes· 2 shared H. Lee· 2 shared I. E. H. Voorhees· 2 shared L. B. Goodman· 2 shared S. Hafenstein· 2 shared A. B. Allison· 1 shared B. K. Alford· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersEvolutionary Biology

C. R. Parrish

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2 papers

Recent·Most cited

Viral capsid, antibody, and receptor interactions: experimental analysis of the antibody escape evolution of canine parvovirus

R. Lopez-Astacio, O. F. Adu, D. J. Goetschius, H. Lee, W. Weichert, B. R. Wasik, S. P. Frueh, B. K. Alford, I. E. H. Voorhees, J. F. Flint, S. Saddoris, L. B. Goodman, E. C. Holmes, S. Hafenstein, C. R. Parrish

This study uses in vitro selection and deep sequencing to identify escape mutations in canine parvovirus selected by two antibodies, revealing mechanisms of antibody and receptor binding interactions.

Journal of Virology · Jun 29, 2023Peer-reviewedEvolutionary Biology

Limited intra-host diversity and background evolution accompany 40 years of canine parvovirus host adaptation and spread

I. E. H. Voorhees, H. Lee, A. B. Allison, R. Lopez-Astacio, L. B. Goodman, O. O. Oyesola, O. Omobowale, O. Fagbohun, E. J. Dubovi, S. Hafenstein, E. C. Holmes, C. R. Parrish

This study analyzes 40 years of canine parvovirus evolution, finding limited intra-host diversity and slow genetic change despite its adaptability.

bioRxiv · Jul 25, 2019Evolutionary Biology