PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma
E. Corrales, E. Levit-Zerdoun, P. Metzger, R. Mertes, A. Lehmann, J. Muench, S. Lemke, S. Kowar, M. Boerries
This study identifies PI3K/AKT pathway activation as a mechanism for MAPK/ERK pathway independency in melanoma, leading to treatment resistance and stem-like properties.
bioRxiv · Jul 8, 2022Cancer Biology