Machine-learning analysis of factors that shape cancer aneuploidy landscapes reveals an important role for negative selection
J. Jubran, R. Slutsky, N. Rozenblum, L. Rokach, U. Ben-David, E. Yeger-Lotem
This study uses machine learning to analyze cancer aneuploidy patterns, revealing that negative selection significantly shapes these landscapes, with tumor-suppressor gene density predicting gain patterns and oncogene density predicting loss patterns.
bioRxiv · Jul 5, 2023Cancer Biology